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(A) Observed (symbols) and simulated (line, module 1–3) inhibition of PNH erythrocyte lysis in vitro as a function of eculizumab concentration. (B) Observed (symbols) and simulated (line, module 1–5) recovery of hemoglobin levels in PNH patients treated for 36 months with eculizumab. The experimental data was digitized from [77] (A) and [74] (B).
