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. 2020 Sep 28;13:385–398. doi: 10.2147/JAA.S242058

Table 3.

Features of Latex Immunotherapy Trials

Route of Administration First Author, Year Study Design Study Population (Active/Control) Age Range (Years) Prevalent Symptoms Induction Phase Maintenance Dose Total Duration Main Results
Percutaneous Patriarca, 200276 Case series 5 26–45 Urticaria–angioedema, asthma, hand eczema Gradual increments starting from 10 s once a day in one hand 1 h, both hands, 3 times a week 1 year Significant clinical improvement with no remarkable side effects
SCIT Leynadier, 200079 RDBPC 9/8 22–41 Rhinitis, conjunctivitis, asthma, angioedema 2 days 100 IR 1 year Decrease in symptoms except for asthma; systemic reaction in 47% in active group
SCIT Sastre, 200380 RDBPC 16/8 21–51 Rhinitis, conjunctivitis, asthma, urticaria 98 days 5±3 to 186±14 µg protein according to max tolerated dose 6 months No change in symptoms, decrease in specific reactivity; systemic reaction in 69% in active group
SCIT Tabar, 200681 RDBPC 11/12 24–58 Rhinitis, conjunctivitis, asthma, urticaria 2 days 80 IR 1 year No significant change in any parameters; systemic reaction in 81.8% in active group
SLIT Patriarca, 200285 RDBPC 12/12 8–64 Rhinitis, asthma, urticaria 4 days 300 µg/week 3 months Challenge tests turned negative; 2 spontaneously resolving local side effects
SLIT Cistero, 200486 Open 26 15–45 Respiratory and cutaneous symptoms 4 days 300 µg/week 2,5 months Significant improvement in glove use; systemic reaction in 3.6% of doses
SLIT Bernardini, 200689 RDBPC 12/8 4–15 Rhinoconjunctivitis, asthma, urticaria 4 days 210 µg/week 1 year Decrease in symptoms; no side effects observed
SLIT Nettis, 200788 RDBPC 20/20 18–47 Asthma, urticaria 4 days 300 µg/week 1 year Decrease in symptoms, significant improvement in glove use; rare local side effects
SLIT Nucera, 200892 Random open 12/11 5–64 Urticaria–angioedema, asthma, rhinoconjunctivitis 2 days vs
3 days
3-day protocol was better tolerated and safer than the 2-day protocol
SLIT Buyukozturk, 201093 RDBPC 8/4 26–32 Rhinitis, conjunctivitis, asthma, urticaria 4 days 300 µg/week 1 year Improvement in glove use, decrease in symptoms; 3 severe systemic events
SLIT Gastaminza, 201197 RDBPC 14/14 24–57 Rhinoconjunctivitis, asthma, urticaria 4 days 210 µg/week 1 year + 1 year No significant difference in any parameters; 4 mild adverse events
SLIT Lasa Luaces, 201294 Open 18/5 Rhinoconjunctivitis, asthma, urticaria 4 days 300 µg/week 1 year Decrease in symptoms, no significant changes in IgE, IgG4 and BAT
SLIT Nucera, 201895 Open 76 Mean age 34 Rhinoconjunctivitis, hand eczema, urticaria 4 days 500 µg/week 3 years Symptoms, provocation tests and mean wheal diameters of SPT significantly improved

Abbreviations: SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy; RDBPC, randomized, double-blind, placebo-controlled; IgE, immunoglobulin E; IgG4, immunoglobulin G4; BAT, basophil activation test; SPT, skin-prick test.