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. 2020 Sep 28;13:369–383. doi: 10.2147/JAA.S272705

Figure 1.

Figure 1

Early shaping of bronchial asthma by microbial exposure. Early-life microbial transfer occurs in utero and during childbirth (maternal intestinal and vaginal flora), during breast feeding (maternal milk microbiome) and contact with animals and soil (environmental microorganisms). These mechanisms allow colonization of commensals during early life. Failure to properly establish early symbiotic relationship with commensals results in dysbiosis and predisposes the host to allergic inflammation and bronchial asthma.