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. 2020 Oct 2;10:16424. doi: 10.1038/s41598-020-73514-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of trigonelline (TGN) on neurofilament light (NFL) levels in the brain. (A) Time course of the experiment. (B) Representative NFL expression in the cerebral cortex by western blotting. Bands at 70 k were quantified as NFL according to the manufacturer’s datasheet. As a loading control, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression was also measured. (C,D) Quantitative values of the expression levels of NFL (ratio to GAPDH) are shown for the cerebral cortex (B) and hippocampus (D). The statistical analysis was performed using a one-way analysis of variance (ANOVA) and post hoc Dunnett’s test, *P < 0.05, **P < 0.01 versus Veh-treated 5XFAD mice, n = 6–7 mice.