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. 2020 Oct 2;11:4952. doi: 10.1038/s41467-020-18682-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Nodes represent ICD-10 codes and each colour corresponds to one of the 21 chapters in the ICD-10 index. Five chapters are excluded (for details, see Methods section). Arrows represent a statistically significant directionality between two diagnosis codes. Numbers describe how many patients follow the trajectories. If an edge is selected manually by clicking (red highlight) the statistical specifications will be displayed in the side panel. In the visualisation interface, selected nodes and edges may also be deleted (grouped or individually) by clicking on the icon “Delete edge”. A description of each variable can be retrieved by placing the curser over the question marks. Search filter settings: all patients, length 3–5, relative risk (RR) 1.5–361, number of patients 21–114,099. ICD-10 International Classification of Diseases, 10th Revision. Colours of nodes represent ICD-10 chapters.