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. 2020 Oct 2;11:4952. doi: 10.1038/s41467-020-18682-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — When an edge is selected, users can explore characteristics for the entire trajectory and the individual trajectory edges separately. In this case, there are 56,251 patients who follow the trajectory I10 -> I50, 24,729 patients that follow the trajectory I10 -> N18 and 4241 patients who follow the trajectory I10 -> I50 -> N18 (visualisation interface). In the Information tab users can find information on the selected length 2 trajectory as well as the entire trajectory (side panel). If users select a different edge or search for I50 or N18, the browser allows to compare e.g. mean age at assignment of first trajectory across all statistically significant trajectories with RR > 1 in the entire population. Search filter settings: all patients, length 4–5, RR 1.15–361, number of patients 4000–114,099. I10: ICD-10 code for essential (primary) hypertension. I50: ICD-10 code for heart failure. N18: ICD-10 code for chronic kidney disease. ICD-10 International Classification of Diseases, 10^th Revision. Colours of nodes represent ICD-10 chapters.