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. 2020 Oct 2;10:16377. doi: 10.1038/s41598-020-72454-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of linezolid on functional and dysfunctional neutrophil killing and phagocytosis. (A) Killing expressed as viable counts of MRSA (cfu/ml). (B) Phagocytosis expressed as the percentage of neutrophils containing MRSA. Data are expressed as the mean ± SEM of 4 separate experiments. White bar represents viable MRSA at t = 0. Hatched bar represents viable MRSA at t = 2 without neutrophils. Grey and black bars represent neutrophils at t = 2 without and with C5a respectively. *Represents a significant difference between viable counts of MRSA at t = 0 versus t = 2 with neutrophils present. **Represents a significant difference between viable counts of MRSA treated with functional and dysfunctional neutrophils at t = 2. ***Represents a significant difference between viable counts of MRSA exposed to dysfunctional neutrophils treated with or without linezolid. # Represents a significant difference in phagocytosis of MRSA by functional and dysfunctional neutrophils. ## Represents a significant difference in the phagocytosis of MRSA by dysfunctional neutrophils with or without linezolid.