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. 2020 Oct 2;10:16389. doi: 10.1038/s41598-020-71764-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Survival analysis based on the combination of δ⁶⁵Cu and δ⁶⁶Zn values. (A) Hierarchical clustering analysis classified HM patients into two groups (G1 and the other group) using the δ⁶⁵Cu and δ⁶⁶Zn values. (B) Survival curves for G1 and the other group obtained by Kaplan-Meier analysis. G1 showed significantly poor survival from the early phase (P = 0.001). (C) Similar classification as in (A), but using the corresponding Cu and Zn concentrations. (D) HM patients were classified into two groups (G2 and the other group). Survival curves for G2 and the other group obtained by Kaplan–Meier analysis. The two groups did not show a significant difference. Patients are numbered according to the δ⁶⁶Zn value (descending order); red coloured numbers correspond to patients in G1; HR, hazard ratio with 95% confidence interval.