Figure 5.
Simulation results of population dynamics in serial transfer experiment of a lytic phage with sensitive, mucoid and resistant bacteria. Changes in the densities of mucoid, M (purple), sensitive, S (blue) and envelope-resistant, NR (green) bacteria and virulent phage, P (red) in populations initially dominated by mucoids. Standard parameters, C = 1000, e = 5 × 107, vS = 2.1, vM = 1.8 and vR = 2.0, k = 1, β = 50, x = 10−5, δS = 10−7. (A) Establishment of the mucoids in a population of sensitive bacteria and phage in the absence of resistance, y = 10−3, δM = 10−11. (B) Establishment of resistant mutants in a population that is unable to generate the mucoids. (C) Establishment of phage in a population dominated by mucoid cells and single sensitive and resistant bacteria, y = 10−3, δM = 10−11. (D) Establishment of phage in a population dominated by mucoid cells and single sensitive and resistant bacteria, y = 10−4, δM = 10−11. (E) Establishment of phage in a population dominated by mucoid cells and single sensitive and resistant bacteria, y = 10−5, δM = 10−11. (F) Establishment of phage in a population dominated by mucoid cells and single sensitive and resistant bacteria, y = 10−3, and dM= 10−10.