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. 2020 Oct 1;33(4):318–325. doi: 10.3344/kjp.2020.33.4.318

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© The Korean Pain Society, 2020

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Antinociceptive effect of intraperitoneal PD 149163 in chemotherapy-induced peripheral neuropathic rats. (A, B) The effect of intraperitoneal PD 149163 (PD: 0, 0.03, 0.1, and 0.3 mg/kg) for the hind paw withdrawal threshold (PWT) to von Frey filaments. (C, D) The effect of intrathecal SR 48692 (SR: 0 or 100 µg) on the antiallodynic effect caused by intraperitoneal PD 149163 (0.3 mg/kg). SR 48692 was delivered 10 minutes before PD 149163 administration. Each line or bar represents mean ± standard error from 6 rats. MPE: maximum possible effect, i.t.: intrathecal administration, i.p.: intraperitoneal administration. *P < 0.05 compared to vehicle.