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. 2020 Oct 1;33(4):318–325. doi: 10.3344/kjp.2020.33.4.318

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© The Korean Pain Society, 2020

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Association between the serotonin (5-hydroxytryptamine) receptor and the antinociceptive effect of intraperitoneal or intrathecal administration of PD 149163. (A, B) The effect of intrathecal dihydroergocristine (DHE: 0 or 30 µg) on the antinociceptive effect of intraperitoneal PD 149163 (PD: 0.3 mg/kg). (C, D) The effect of intrathecal dihydroergocristine (30 µg) on the antinociceptive effect of intrathecal PD 149163 (30 ng). Dihydroergocristine was delivered 10 minutes before PD 149163 administration. Each line or bar represents mean ± standard error of 6-7 rats. PWT: paw withdrawal threshold, MPE: maximum possible effect, i.t.: intrathecal administration, i.p.: intraperitoneal administration. *P < 0.05 compared to vehicle. ^#P < 0.05 compared to PD 149163 (i.t.)-treated group.