Figure 3.

Figure illustrating the virus binding to the target receptor (ACE-2) on the surface of the target cell with its spike proteins. The viral particle is then internalized by endocytosis by the fusion of S protein of the viral envelope with cell membrane followed by the translation of the viral genomic RNA to produce a virus-specific RNA-dependent RNA polymerase which transcribes a full-length complementary minus-strand RNA which then interacts within the cytoplasm of the cell with the viral nucleocapsid protein to form helical nucleocapsids. These nucleocapsids bud in the compartment through the membranes of the rough endoplasmic reticulum (ER) and the Golgi apparatus in areas that contain the viral glycoprotein (ERGIC). Mature virion synthesized are then transported in the vesicles to the cell periphery for the release upon the cell lysis.