Table 3.
Review of Published Articles on Ocular Prospective of SARS-CoV 2 Infection
| S No. | Article Title and Authors |
Published Journal | Article Type/Design | Study Period | Place of Study | Mean Age/Range Years | Novel Corona Pneumonia cases | Presence of Ocular Features | Ocular Sample RT PCR + | Ocular Viral load |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
Clinical Characteristics of Coronavirus Disease 2019 in China (Guan et al)40 |
The New England Journal of Medicine | Original article/Cohort Study | 11th Dec 2019–29th Jan 2020 | 47 (Range, 35–58) | 1099 (926 non severe and 173 severe patients) | 9/1099 (0.8%) 5(0.5% in Non severe) and 4(2.3% in Severe) cases |
Not Mentioned | Low | |
| 2 |
There may be virus in conjunctival secretion of patients with COVID-19 (Liang L et al)41 |
Acta Ophthalmologica 2020 (Perspective In Ophthalmology) |
Cohort Study | Not Mentioned | Yichang Central People’s Hospital, China | Not Mentioned | 37 (12 severe, 15 mild cases) | 3 | 1 conjunctival sac secretion nucleic acid test +ve | Low |
| 3 |
Comparisons of nucleic acid conversion time of SARS-CoV-2 of different samples in ICU and non-ICU patient (Fang et al)42 |
Journal of Infection | Letter to the Editor | Jan–Feb 2020 | Central Hospital of Xiangtan |
34–54 years | 32 (8 ICU & 24r non-ICU) | Not Mentioned | The positive rate of tears (15.6%, 5/32) | Not Mentioned |
| 4 |
Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China (Wu P et al)8 |
JAMA Ophthalmology | Brief Report/Prospective | 9–15th Feb 2020 | Yichang Central People’s Hospital, China | 65.8± 16.6 | 38 | 12 (31.6%) | 2 patients (5.2%;95% CI, 0.617.8) in conjunctival specimen | Not Mentioned |
| 5 |
Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection (Xia J et al)31 |
Journal of Medical Virology | Prospective, Case-series | 26th Jan–9th Feb | Hospital of Zhejiang University, China | 54.50±14.17 | 30 | 1(3.3%) | 1 (3.3%) in conjunctival swab | Not Mentioned |
| 6 |
Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva (Zhou Y et al)9 |
MedRxiv | Retrospective cohort study | 17−28th Jan 2020 | Renmin Hospital of Wuhan University, China | 35.7± 10.6 | 67 | 1(1.5%) | 3 (4.4%) 1 Positive 2 Probable Positive |
Not mentioned |
| 7 |
Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals (Seah I et al)30 |
Ocular Immunology And Inflammation | Invited Review | Not Mentioned | Singapore | Feline& Murine eyes | Live Corona virus isolated in cats and mice eyes | – | – | – |
| 8 |
Ocular manifestation, eye protection, and COVID-19 (Mungmungpuntipantip R et al)43 |
Graefe’s Archive for Clinical and Experimental Ophthalmology | Letter to Editor | March | 26 Medical Center, Bangkok, Thailand | Not mentioned | 48 | No Ocular findings | 0% | 0 |
| 9 |
Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear (Li JO et al)44 |
British Journal of Ophthalmology | Editorial | Not Mentioned | Not Mentioned | Not Mentioned | Not Mentioned | Not Mentioned | Not Mentioned | Not Mentioned |
| 10 |
The evidence of SARS-CoV-2 infection on ocular surface (Zhang X et al)10 |
Ocular Surface | Cohort study | Not Mentioned | Tongji Hospital, Wuhan, China | Not Mentioned | 72 | 2 (2.78%) | 1 | Not mentioned |
| 11 |
Screening for novel coronavirus related conjunctivitis among the patients with corona virusdisease-19 (Lan QQ et al)45 |
Chinese Medical Association Publishing House Ltd. | Prospective, Case-series | Not Mentioned | Guangxi Zhuang Autonomous Region, Nanning | Not Mentioned | 81 | 3 | 0 | Not mentioned |
| 12 |
Assessing Viral Shedding and Infectivity of Tears in Coronavirus Disease 2019 (COVID-19) Patients (Seah IYJ et al)37 |
Ophthalmology | Prospective, Case-series | Not Mentioned | National University Hospital, Singapore, Republic of Singapore | Not Mentioned | 17 | 1 | 0 | Not Mentioned |