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. 2020 Sep 28;14:3983–3993. doi: 10.2147/DDDT.S264077

Figure 6.

Figure 6

Molecular dynamics simulation to determine the effect of compound 7594–0037 on c-Myc protein stability. (A) Compound 7594–0037 interacted with the N-terminus rather than the C-terminus of c-Myc protein. (B–D) RMSD of the backbone atoms of (B) c-Myc whole protein, (C) the N-terminus, and (D) the C-terminus with the reference structure at t = 0 ns in two systems: c-Myc/7594-0037 (black) and single c-Myc protein (red).