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Compound 7594–0037 interrupted the binding interactions between the N- and C-termini of c-Myc protein. (A) The detailed binding interactions at the two termini of c-Myc. (B) Compound 7594–0037 inserted into the interface of the two termini, and cleaved the hydrogen bond formed by residues Leu917 and Lys939. The N- and C-termini of c-Myc are shown in cartoon models, and colored in blue and magenta, respectively.
