Table 1.
Gene expression profiling of MNCs in the presence or absence of PMP treatment.
| Molecular and cellular function | Fold enrichment | P-value | Number of molecules | FDR |
|---|---|---|---|---|
| Blood coagulation | 1.739779 | 1.24E−09 | 184/486 | 4.80E−06 |
| Innate immune response | 1.538794 | 1.30E−08 | 257/770 | 2.51E−05 |
| Immune response | 1.834004 | 2.47E−08 | 130/324 | 3.18E−05 |
| Inflammatory response | 1.811905 | 3.40E−08 | 132/333 | 3.28E−05 |
| Platelet activation | 1.966704 | 2.15E−07 | 92/213 | 0.000166 |
| Signal transduction | 1.419512 | 4.08E−07 | 300/974 | 0.000263 |
| Cytokine-mediated signaling pathway | 1.797146 | 1.24E−06 | 103/261 | 0.000685 |
| Type I interferon signaling pathway | 2.691139 | 1.74E−06 | 41/69 | 0.000843 |
| Adaptive immune response | 2.064937 | 6.37E−06 | 61/134 | 0.002737 |
| Response to lipopolysaccharide | 1.979213 | 9.54E−06 | 65/149 | 0.003686 |
The functional summary of the differentially expressed mRNAs (>1.2-fold or <0.833-fold changes) is shown. The PANTHER Classification System (http://pantherdb.org/) was used for Gene Ontology analysis.