Table 1.

Clinical characterization of NDI patients with V2R mutation in this study.

Case	1	2	3	4	5
Name	L86P	M272R	W323_I324insR	R113Q	C192S
Type of mutation	Missense	Missense	In-frame insertion	Missense	Missense
Locationa	TM2	TM6	TM7	ECL1	ECL2
Gender	M	M	M	M	M
Time to diagnosis	1 month	6 months	1.5 months	15 years	18 months
Serum Na+ (mM)	156	156	167	155	156
Serum Osm (mOsm/KgH2O)	316	320	345	315	317
U Osm pre dDAVP (mOsm/KgH2O)	229	65	82	140	120
U Osm post dDAVP (mOsm/KgH2O)	158	86	64	162	150

^aTM, transmembrane; ECL, extracellular loop.