Table 7.

Subgroup analysis of studies on periodontitis and HM

Subgroup	No. of studies	Heterogeneity		Model	Meta-analysis
		I2 (95%CI)	p		HR	95%CI	p
Overall analysis	5	0% (0%-79%)	0.61	Random	1.19	1.09-1.29	<0.0001
Mean age
<60	2	0%	0.38	Random	1.23	1.11-1.37	0.0001
≥60	3	0% (0%-90%)	0.75	Random	1.11	0.96-1.28	0.15
Sex
Male	2	0%	0.38	Random	1.33	1.14-1.54	0.0003
Female	3	0% (0%-90%)	0.51	Random	1.09	0.93-1.27	0.27
Periodontitis severity
Mild/moderate	2	0%	0.45	Random	1.08	071-1.65	0.73
Severe	2	0%	0.50	Random	1.47	0.92-2.33	0.11
Adjusted covariates
With smoking status	4	0% (0%-85%)	0.45	Random	1.19	1.07-1.33	0.001
With socio-economic status	4	0% (0%-85%)	0.82	Random	1.14	1.03-1.27	0.009
Smoking status
Non-smokers	3	0% (0%-90%)	0.63	Random	1.30	1.14-1.48	0.0001
Follow-up years
≤10	2	0%	0.42	Random	1.13	1.02-1.26	0.02
>10	3	0% (0%-90%)	0.96	Random	1.29	1.12-1.48	0.0004
Sample size
<10000	2	0%	1.00	Random	1.24	0.91-1.69	0.18
≥10000	3	23% (0%-70%)	0.27	Random	1.18	1.07-1.31	0.001
Hematologic cancers sub-types
Leukemia	2	0%	0.38	Random	1.21	0.98-1.49	0.08
Non-Hodgkin lymphoma	2	44% (0%-85%)	0.21	Random	1.20	1.01-1.43	0.04
Multiple myeloma	2	0%	0.44	Random	1.17	0.89-1.54	0.27

No. of studies: the number of studies.