Table 7.
The functional annotation clustering of CGs
| Annotation Cluster | Term | Count | P-value |
|---|---|---|---|
| Annotation Cluster 1 (Score:6.04) | Asthma|Bronchiolitis, Viral|Respiratory Syncytial Virus Infections | 7 | 8.50E-07 |
| respiratory syncytial virus bronchiolitis | 7 | 8.50E-07 | |
| Bronchiolitis, Viral|Respiratory Syncytial Virus Infections | 7 | 1.04E-06 | |
| Annotation Cluster 2 (Score:4.91) | Coronary Artery Disease|Inflammation | 5 | 5.45E-07 |
| non-Hodgkin lymphoma | 4 | 1.90E-06 | |
| Recurrence|Venous Thromboembolism | 5 | 2.48E-06 | |
| Arthritis | 5 | 2.66E-06 | |
| Brain Ischemia|Hypertension|Osteoporosis|Stroke | 5 | 3.69E-06 | |
| diabetes, type 1 | 6 | 1.38E-05 | |
| melanoma | 5 | 2.10E-05 | |
| Inflammation|Venous Thromboembolism | 4 | 2.24E-05 | |
| Chlamydia Infections|Inflammation|Trachoma | 4 | 2.24E-05 | |
| Brain Ischemia|Inflammation|Stroke | 4 | 2.24E-05 | |
| Pre-Eclampsia | 4 | 3.32E-04 | |
| Migraine Disorders | 4 | 4.52E-04 | |
| Annotation Cluster 3 (Score:4.89) | Chorioamnionitis|Fetal Membranes, Premature Rupture|Infection of amniotic sac and membranes | 7 | 4.94E-07 |
| Chorioamnionitis|Fetal Membranes, Premature Rupture|Infection of amniotic sac and membranes|Obstetric Labor, Premature|Pre-Eclampsia|Premature Birth | 7 | 5.10E-07 | |
| Coronary Artery Disease | 7 | 1.56E-04 | |
| Alzheimer's disease | 8 | 7.10E-04 | |
| Annotation Cluster 4 (Score:4.44) | Hodgkin Disease|Inflammation | 4 | 3.40E-06 |
| Sarcoidosis | 5 | 4.99E-06 | |
| Adenocarcinoma|Stomach Neoplasms | 4 | 5.74E-05 | |
| kidney failure, chronic | 5 | 2.02E-04 | |
| esophageal cancer | 4 | 3.20E-04 | |
| Annotation Cluster 5 (Score:4.26) |
Lymphoma, Non-Hodgkin|Lymphoma, Non-Hodgkin's | 5 | 3.30E-05 |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive|Neovascularization, Pathologic | 4 | 4.02E-05 | |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 4 | 1.29E-04 | |
| Annotation Cluster 6 (Score:4.09) | Tuberculosis, Pulmonary | 5 | 2.31E-06 |
| systemic lupus erythematosus | 5 | 8.88E-05 | |
| hepatitis C, chronic | 4 | 3.56E-04 | |
| Tuberculosis | 4 | 6.16E-04 | |
| Annotation Cluster 7 (Score:4.04) | Helicobacter Infections|Inflammation|Precancerous Conditions|Stomach Neoplasms | 4 | 9.23E-07 |
| Stomach Neoplasms | 5 | 3.54E-05 | |
| patent ductus arteriosus | 5 | 6.13E-05 | |
| Cystic Fibrosis | 4 | 1.29E-04 | |
| stomach cancer | 4 | 5.46E-04 | |
| rheumatoid arthritis | 4 | 0.003880586 | |
| Annotation Cluster 8 (Score:3.94) | Infection|Inflammation|Premature Birth | 5 | 5.26E-05 |
| Inflammation|Premature Birth | 5 | 5.77E-05 | |
| Connective Tissue Diseases|Fetal Diseases|Inflammation|Musculoskeletal Diseases|Pregnancy Complications, Hematologic|Premature Birth|Skin Diseases | 5 | 5.77E-05 | |
| Asthma | 4 | 9.96E-04 | |
| Annotation Cluster 9 (Score:3.84) | Atherosclerosis | 7 | 2.07E-05 |
| Myocardial Infarction | 7 | 2.05E-04 | |
| Alzheimer's disease | 8 | 7.10E-04 | |
| Annotation Cluster 10 (Score:3.78) | Brain Ischemia|Stroke | 5 | 1.86E-05 |
| Peripheral Vascular Diseases | 4 | 4.02E-05 | |
| Cardiovascular Diseases | 5 | 2.60E-04 | |
| Hypercholesterolemia|LDLC levels | 4 | 0.004054968 | |
| Annotation Cluster 11 (Score:3.55) | Restenosis | 4 | 1.81E-04 |
| Arthritis, Rheumatoid|Rheumatoid Arthritis | 5 | 1.98E-04 | |
| Endometriosis | 4 | 6.16E-04 | |
| Annotation Cluster 12 (Score:3.28) | Alcoholism|Liver Cirrhosis, Alcoholic | 3 | 2.12E-04 |
| Esophageal Neoplasms|Hyperglycemia|Oesophageal neoplasm | 3 | 2.12E-04 | |
| Biliary Tract Neoplasms|Inflammation | 3 | 5.66E-04 | |
| Arthritis, Psoriatic|Psoriatic arthropathy | 3 | 6.21E-04 | |
| cardiovascular | 3 | 0.002488197 | |
| Annotation Cluster 13 (Score:3.18) | Otitis Media|Recurrence | 3 | 2.47E-04 |
| Brucellosis | 3 | 5.12E-04 | |
| Graft vs Host Disease|Hematologic Neoplasms|Neoplasm Recurrence, Local | 3 | 5.12E-04 | |
| Kawasaki disease | 3 | 6.21E-04 | |
| Atopy | 3 | 0.003077333 | |
| Annotation Cluster 14 (Score:2.82) | Atherosclerosis|Inflammation|Retinal Vein Occlusion | 3 | 1.23E-04 |
| Dermatitis, Atopic|Eczema allergic | 3 | 7.41E-04 | |
| juvenile arthritis | 3 | 0.001084437 | |
| graft-versus-host disease | 3 | 0.002834545 | |
| Graft vs Host Disease | 3 | 0.005354403 | |
| hepatitis C | 3 | 0.008600238 | |
| Annotation Cluster 15 (Score:2.80) | Uveitis, Anterior | 3 | 1.23E-04 |
| Pancreatitis, Chronic | 3 | 8.05E-04 | |
| stroke, ischemic | 3 | 0.004142278 | |
| Glomerulonephritis, IGA | 3 | 0.016033469 | |
| Annotation Cluster 16 (Score:2.76) | giant cell arteritis | 3 | 5.12E-04 |
| Malaria, Falciparum | 3 | 0.002163435 | |
| Malaria | 3 | 0.004882851 | |
| Annotation Cluster 17 (Score:2.72) | Cardiovascular Diseases|Inflammation | 3 | 1.50E-04 |
| skin cancer, non-melanoma | 3 | 0.001084437 | |
| Adenoma|Colorectal Neoplasms | 3 | 0.002954755 | |
| Depression | 3 | 0.028362664 | |
| Annotation Cluster 18 (Score:2.68) | Endometriosis|Uterine Diseases | 3 | 1.50E-04 |
| Hepatitis B, Chronic | 3 | 0.006357795 | |
| Pulmonary Disease, Chronic Obstructive | 3 | 0.009415863 | |
| Annotation Cluster 19 (Score:2.63) | respiratory syncytial virus | 3 | 3.68E-04 |
| Q fever | 3 | 4.61E-04 | |
| Graves' disease|Graves' disease | 3 | 0.001490775 | |
| Graves' disease | 3 | 0.001579503 | |
| Diabetes Mellitus, Insulin-Dependent|Diabetes Mellitus, Type 1 | 3 | 0.006532757 | |
| Premature Birth | 3 | 0.01182929 | |
| Kidney Diseases | 3 | 0.012294446 | |
| Annotation Cluster 20 (Score:2.47) | Carcinoma, Squamous Cell|Mouth Neoplasms | 3 | 0.001084437 |
| Helicobacter Infections|Stomach Neoplasms | 3 | 0.002377534 | |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | 0.015509841 |