Table 3.
Multivariable Cox regression analysis of all-caused and ovarian cancer-specific survival in patients with ovarian cancer.
| Characteristics | All-cause adjusted HR | P | OC-specific adjusted HR | P |
|---|---|---|---|---|
| Previous malignancy | ||||
| Yes | Reference | Reference | ||
| No | 0.92 (0.87, 0.97) | 0.003 | 0.83 (0.78, 0.88) | <0.001 |
| Age at diagnosis | <0.001 | <0.001 | ||
| 18-40 | Reference | Reference | ||
| 41-65 | 1.54 (1.44, 1.65) | <0.001 | 1.47 (1.37, 1.58) | <0.001 |
| >65 | 1.15 (1.12, 1.19) | <0.001 | 2.13 (1.99, 2.29) | <0.001 |
| Race | <0.001 | <0.001 | ||
| White | Reference | Reference | ||
| Black | 1.18 (1.14, 1.23) | <0.001 | 1.16 (1.11, 1.21) | <0.001 |
| AI/AN | 1.10 (0.96, 1.26) | 0.177 | 1.08 (0.94, 1.25) | 0.292 |
| AP | 0.93 (0.88, 0.97) | 0.001 | 0.91 (0.86, 0.95) | <0.001 |
| Unknown | 0.25 (0.18, 0.35) | <0.001 | 0.24 (0.17, 0.35) | <0.001 |
| CA-125 | <0.001 | <0.001 | ||
| Elevated | Reference | Reference | ||
| Normal | 0.61 (0.58, 0.65) | <0.001 | 0.61 (0.57, 0.65) | <0.001 |
| Unknown | 0.82 (0.80, 0.84) | <0.001 | 0.81 (0.79, 0.84) | <0.001 |
| Histologic Type | <0.001 | <0.001 | ||
| Epithelial | Reference | Reference | ||
| Sex-cord-stromal | 0.41 (0.35, 0.48) | <0.001 | 0.37 (0.31, 0.44) | <0.001 |
| Germ-cell | 0.32 (0.25, 0.40) | <0.001 | 0.28 (0.22, 0.37) | <0.001 |
| Others | 1.15 (1.12, 1.18) | <0.001 | 1.16 (1.12, 1.19) | <0.001 |
| Tumour Size | <0.001 | <0.001 | ||
| 0-1 mm | Reference | Reference | ||
| 1-5 mm | 1.40 (1.29, 1.52) | <0.001 | 1.40 (1.29, 1.53) | <0.001 |
| 5-10 mm | 1.33 (1.23, 1.44) | <0.001 | 1.32 (1.21, 1.43) | <0.001 |
| 10-20 mm | 1.28 (1.19, 1.39) | <0.001 | 1.28 (1.17, 1.39) | <0.001 |
| >20 mm | 1.50 (1.36, 1.65) | <0.001 | 1.46 (1.32, 1.62) | <0.001 |
| Unknown | 1.43 (1.33, 1.54) | <0.001 | 1.43 (1.33, 1.32) | <0.001 |
| AJCC stage (6th) | <0.001 | <0.001 | ||
| I | Reference | Reference | ||
| II | 2.10 (1.95, 2.26) | <0.001 | 2.46 (2.26, 2.67) | <0.001 |
| III | 4.32 (4.09, 4.57) | <0.001 | 5.40 (5.07, 5.76) | <0.001 |
| IV | 5.94 (5.62, 6.29) | <0.001 | 7.53 (7.06, 8.04) | <0.001 |
| Others | 4.46 (4.21, 4.21) | <0.001 | 5.54 (5.18, 5.91) | <0.001 |
| Grade | <0.001 | <0.001 | ||
| I | Reference | Reference | ||
| II | 1.82 (1.66, 1.99) | <0.001 | 1.99 (1.80, 2.21) | <0.001 |
| III | 2.18 (2.00, 2.37) | <0.001 | 2.43 (2.21, 2.68) | <0.001 |
| IV | 2.15 (1.97, 2.35) | <0.001 | 2.40 (2.17, 2.65) | <0.001 |
| V | 1.95 (1.79, 2.12) | <0.001 | 2.17 (1.97, 2.39) | <0.001 |
| Surgery | <0.001 | <0.001 | ||
| Yes | Reference | Reference | ||
| No | 2.91 (2.81, 3.02) | <0.001 | 2.92 (2.81, 3.03) | <0.001 |
| Unknown | 1.53 (1.35, 1.74) | <0.001 | 1.51 (1.32, 1.73) | <0.001 |
| Radiation | <0.001 | <0.001 | ||
| Yes | Reference | Reference | ||
| No | 0.76 (0.68, 0.84) | <0.001 | 0.76 (0.68, 0.85) | <0.001 |
| Unknown | 0.50 (0.28, 0.89) | 0.018 | 0.45 (0.24, 0.86) | 0.014 |
| Chemotherapy | ||||
| Yes | Reference | Reference | ||
| No/Unknown | 1.65 (1.61, 1.70) | <0.001 | 1.61 (1.56, 1.65) | <0.001 |
| Insurance | <0.001 | <0.001 | ||
| Yes | Reference | Reference | ||
| No | 1.12 (1.04, 1.21) | 0.002 | 1.11 (1.03, 1.20) | 0.007 |
| Unknown | 1.06 (1.04, 1.09) | <0.001 | 1.07 (1.04, 1.10) | <0.001 |
| Marital status | <0.001 | <0.001 | ||
| Married | Reference | Reference | ||
| Unmarried | 1.16 (1.14, 1.19) | <0.001 | 1.14 (1.11, 1.17) | <0.001 |
| Unknown | 0.92 (0.87, 0.98) | 0.006 | 0.88 (0.82, 0.93) | <0.001 |
Abbreviation: OC, Ovarian cancer; AI/AN, American Indian/Alaska Native; AP, Asian or Pacific Islander; CA-125, Cancer Antigen 125; Grade: I, well differentiated; II, moderately differentiated; III, poorly differentiated; IV, undifferentiated; V, unknown.