Table 2.
Univariable and multivariable Cox regression model analyses of OS for nomogram
| Characteristics | Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI lower | 95% CI upper | p-value | OR | 95% CI lower | 95% CI upper | p-value | |
| Gender | 0.118 | |||||||
| Female | Reference | NA | ||||||
| Male | 0.952 | 0.895 | 1.013 | 0.118 | ||||
| Age (years) | <0.001 | <0.001 | ||||||
| ≤50 | Reference | Reference | ||||||
| 51-60 | 1.137 | 1.027 | 1.260 | 0.014 | 1.095 | 0.987 | 1.214 | 0.086 |
| 61-70 | 1.311 | 1.188 | 1.447 | <0.001 | 1.225 | 1.108 | 1.355 | <0.001 |
| 71-80 | 1.846 | 1.666 | 2.045 | <0.001 | 1.597 | 1.434 | 1.778 | <0.001 |
| >80 | 3.294 | 2.951 | 3.677 | <0.001 | 2.124 | 1.874 | 2.408 | <0.001 |
| Marital status | <0.001 | <0.001 | ||||||
| Married | Reference | Reference | ||||||
| Single | 1.238 | 1.139 | 1.345 | <0.001 | 1.259 | 1.155 | 1.372 | <0.001 |
| Divorced/Separated | 1.150 | 1.041 | 1.271 | 0.006 | 1.123 | 1.015 | 1.243 | 0.024 |
| Widowed | 1.887 | 1.722 | 2.067 | <0.001 | 1.102 | 0.998 | 1.218 | 0.056 |
| NOS | 1.141 | 0.989 | 1.316 | 0.071 | 1.065 | 0.923 | 1.230 | 0.389 |
| Insurance | 0.405 | |||||||
| Yes | Reference | NA | ||||||
| No/unknown | 0.944 | 0.825 | 1.081 | 0.405 | ||||
| Race | <0.001 | <0.001 | ||||||
| White | Reference | Reference | ||||||
| Black | 1.215 | 1.119 | 1.320 | <0.001 | 1.179 | 1.082 | 1.285 | <0.001 |
| Other/NOS | 0.890 | 0.795 | 0.996 | 0.042 | 0.892 | 0.797 | 1.000 | 0.049 |
| Tumor location | <0.001 | <0.001 | ||||||
| Right colon | Reference | Reference | ||||||
| Left colon | 0.645 | 0.600 | 0.692 | <0.001 | 0.743 | 0.689 | 0.800 | <0.001 |
| Rectum † | 0.682 | 0.630 | 0.738 | <0.001 | 0.787 | 0.719 | 0.862 | <0.001 |
| NOS | 1.372 | 1.104 | 1.705 | 0.004 | 1.227 | 0.985 | 1.527 | 0.068 |
| Pathological grade | <0.001 | <0.001 | ||||||
| I | Reference | Reference | ||||||
| II | 0.942 | 0.801 | 1.108 | 0.471 | 1.097 | 0.931 | 1.292 | 0.269 |
| III | 1.418 | 1.195 | 1.683 | <0.001 | 1.498 | 1.257 | 1.785 | <0.001 |
| IV | 1.903 | 1.539 | 2.353 | <0.001 | 2.066 | 1.661 | 2.568 | <0.001 |
| Unknown | 1.325 | 1.097 | 1.599 | 0.003 | 1.122 | 0.925 | 1.360 | 0.243 |
| Histological type | <0.001 | 0.018 | ||||||
| Adenocarcinomas | Reference | Reference | ||||||
| MCC/SRCC | 1.329 | 1.175 | 1.504 | <0.001 | 1.165 | 1.027 | 1.322 | 0.018 |
| T stage | <0.001 | <0.001 | ||||||
| T1 | Reference | Reference | ||||||
| T2 | 0.436 | 0.358 | 0.531 | <0.001 | 0.771 | 0.623 | 0.953 | 0.016 |
| T3 | 0.559 | 0.507 | 0.616 | <0.001 | 0.850 | 0.746 | 0.969 | 0.015 |
| T4a | 0.822 | 0.735 | 0.918 | 0.001 | 1.158 | 1.002 | 1.339 | 0.048 |
| T4b | 0.808 | 0.712 | 0.916 | 0.001 | 1.066 | 0.922 | 1.232 | 0.387 |
| N stage | <0.001 | <0.001 | ||||||
| N0 | Reference | Reference | ||||||
| N1a | 0.805 | 0.724 | 0.894 | <0.001 | 1.150 | 1.026 | 1.289 | 0.017 |
| N1b | 0.934 | 0.853 | 1.023 | 0.140 | 1.319 | 1.188 | 1.465 | <0.001 |
| N1c | 0.863 | 0.680 | 1.094 | 0.223 | 1.147 | .900 | 1.463 | 0.267 |
| N2a | 1.024 | 0.934 | 1.123 | 0.608 | 1.487 | 1.336 | 1.656 | <0.001 |
| N2b | 1.327 | 1.218 | 1.445 | <0.001 | 1.905 | 1.715 | 2.116 | <0.001 |
| Colectomy | <0.001 | <0.001 | ||||||
| Standard colectomy | Reference | Reference | ||||||
| Simplified colectomy | 1.245 | 1.142 | 1.358 | <0.001 | 1.343 | 1.229 | 1.469 | <0.001 |
| Non-colectomy/NOS | 1.964 | 1.817 | 2.123 | <0.001 | 2.599 | 2.288 | 2.953 | <0.001 |
| Hepatic surgery | <0.001 | <0.001 | ||||||
| Yes | Reference | Reference | ||||||
| No/unknown | 1.971 | 1.807 | 2.150 | <0.001 | 1.502 | 1.373 | 1.643 | <0.001 |
| Radiotherapy | <0.001 | .100 | ||||||
| Yes | Reference | Reference | ||||||
| No/Unknown | 1.476 | 1.319 | 1.651 | <0.001 | 1.110 | 0.980 | 1.256 | 0.100 |
| Chemotherapy | <0.001 | <0.001 | ||||||
| Yes | Reference | Reference | ||||||
| No/Unknown | 2.850 | 2.669 | 3.044 | <0.001 | 2.387 | 2.223 | 2.563 | <0.001 |
| CEA | <0.001 | <0.001 | ||||||
| Negative | Reference | Reference | ||||||
| Positive | 1.697 | 1.532 | 1.880 | <0.001 | 1.624 | 1.465 | 1.801 | <0.001 |
| NOS | 1.666 | 1.492 | 1.860 | <0.001 | 1.476 | 1.321 | 1.649 | <0.001 |
| PNI | <0.001 | 0.412 | ||||||
| Negative | Reference | Reference | ||||||
| Positive | 1.091 | 1.011 | 1.178 | 0.025 | 1.043 | 0.964 | 1.129 | 0.293 |
| NOS | 1.403 | 1.297 | 1.518 | <0.001 | 0.970 | 0.885 | 1.064 | 0.521 |
MCC: mucinous cell carcinoma; SRCC: signet ring cell carcinoma; RNE: regional nodes examined; PNI: perineural invasion; NOS: not otherwise specified; NA: Unavailable.
†: Rectum includes Rectosigmoid junction.