Table 3.
Univariable and multivariable Cox regression model analyses of CSS for nomogram
| Characteristics | Univariable analysis | Multivariable analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI lower | 95% CI upper | p-value | OR | 95% CI lower | 95% CI upper | p-value | |
| Gender | 0.060 | |||||||
| Female | Reference | NA | ||||||
| Male | 0.935 | 0.872 | 1.003 | 0.060 | ||||
| Age (years) | <0.001 | <0.001 | ||||||
| ≤50 | Reference | Reference | ||||||
| 51-60 | 1.111 | 0.997 | 1.238 | 0.057 | 1.065 | 0.954 | 1.189 | 0.259 |
| 61-70 | 1.242 | 1.117 | 1.382 | <0.001 | 1.151 | 1.032 | 1.283 | 0.011 |
| 71-80 | 1.777 | 1.585 | 1.992 | <0.001 | 1.503 | 1.333 | 1.695 | <0.001 |
| >80 | 3.221 | 2.835 | 3.660 | <0.001 | 2.070 | 1.790 | 2.395 | <0.001 |
| Marital status | <0.001 | <0.001 | ||||||
| Married | Reference | Reference | ||||||
| Single | 1.261 | 1.150 | 1.383 | <0.001 | 1.262 | 1.147 | 1.388 | <0.001 |
| Divorced/Separated | 1.142 | 1.018 | 1.281 | 0.024 | 1.083 | 0.964 | 1.217 | 0.181 |
| Widowed | 1.949 | 1.749 | 2.171 | <0.001 | 1.159 | 1.030 | 1.304 | 0.015 |
| NOS | 1.127 | 0.959 | 1.326 | 0.147 | 1.030 | .875 | 1.213 | 0.722 |
| Insurance | 0.857 | |||||||
| Yes | Reference | NA | ||||||
| No/unknown | 0.987 | 0.852 | 1.142 | 0.857 | ||||
| Race | <0.001 | <0.001 | ||||||
| White | Reference | Reference | ||||||
| Black | 1.257 | 1.146 | 1.378 | <0.001 | 1.166 | 1.059 | 1.283 | 0.002 |
| Other/NOS | 0.902 | 0.795 | 1.023 | 0.109 | 0.852 | 0.750 | 0.968 | 0.014 |
| Tumor location | <0.001 | <0.001 | ||||||
| Right colon | Reference | Reference | ||||||
| Left colon | 0.621 | 0.572 | 0.673 | <0.001 | 0.719 | 0.660 | 0.782 | <0.001 |
| Rectum † | 0.674 | 0.616 | 0.737 | <0.001 | 0.751 | 0.677 | 0.833 | <0.001 |
| NOS | 1.408 | 1.096 | 1.810 | 0.007 | 1.244 | 0.965 | 1.604 | 0.092 |
| Pathological grade | <0.001 | <0.001 | ||||||
| I | Reference | Reference | ||||||
| II | 0.937 | 0.780 | 1.124 | 0.482 | 1.101 | 0.915 | 1.324 | 0.310 |
| III | 1.434 | 1.182 | 1.740 | <0.001 | 1.527 | 1.253 | 1.861 | <0.001 |
| IV | 1.899 | 1.493 | 2.415 | <0.001 | 1.942 | 1.517 | 2.485 | <0.001 |
| Unknown | 1.274 | 1.028 | 1.579 | .027 | 1.089 | 0.873 | 1.359 | 0.451 |
| Histological type | <0.001 | 0.017 | ||||||
| Adenocarcinomas | Reference | Reference | ||||||
| MCC/SRCC | 1.315 | 1.142 | 1.514 | <0.001 | 1.193 | 1.033 | 1.378 | 0.017 |
| T stage | <0.001 | <0.001 | ||||||
| T1 | Reference | Reference | ||||||
| T2 | 0.412 | 0.325 | 0.522 | <0.001 | 0.702 | 0.544 | 0.905 | 0.006 |
| T3 | 0.548 | 0.489 | 0.613 | <0.001 | 0.799 | 0.685 | 0.931 | 0.004 |
| T4a | 0.810 | 0.713 | 0.921 | 0.001 | 1.100 | 0.927 | 1.304 | 0.275 |
| T4b | 0.786 | 0.680 | 0.909 | 0.001 | 1.032 | 0.874 | 1.218 | 0.711 |
| N stage | <0.001 | <0.001 | ||||||
| N0 | Reference | Reference | ||||||
| N1a | 0.822 | 0.728 | 0.927 | 0.001 | 1.183 | 1.038 | 1.348 | 0.012 |
| N1b | 0.943 | 0.850 | 1.047 | 0.270 | 1.309 | 1.160 | 1.477 | <0.001 |
| N1c | 0.871 | 0.665 | 1.140 | 0.315 | 1.083 | 0.821 | 1.428 | 0.572 |
| N2a | 1.034 | 0.930 | 1.149 | 0.538 | 1.485 | 1.314 | 1.679 | <0.001 |
| N2b | 1.391 | 1.263 | 1.532 | <0.001 | 1.989 | 1.765 | 2.241 | <0.001 |
| Colectomy | <0.001 | <0.001 | ||||||
| Standard colectomy | Reference | Reference | ||||||
| Simplified colectomy | 1.222 | 1.106 | 1.350 | <0.001 | 1.338 | 1.207 | 1.484 | <0.001 |
| Non-colectomy/NOS | 1.984 | 1.814 | 2.170 | <0.001 | 2.714 | 2.349 | 3.136 | <0.001 |
| Hepatic surgery | <0.001 | <0.001 | ||||||
| Yes | Reference | Reference | ||||||
| No/unknown | 1.960 | 1.776 | 2.162 | <0.001 | 1.479 | 1.336 | 1.637 | <0.001 |
| Radiotherapy | <0.001 | 0.235 | ||||||
| Yes | Reference | Reference | ||||||
| No/Unknown | 0.666 | 0.586 | 0.757 | <0.001 | 1.090 | 0.945 | 1.258 | 0.235 |
| Chemotherapy | <0.001 | <0.001 | ||||||
| Yes | Reference | Reference | ||||||
| No/Unknown | 2.843 | 2.635 | 3.068 | <0.001 | 2.412 | 2.221 | 2.620 | <0.001 |
| CEA | <0.001 | <0.001 | ||||||
| Negative | Reference | Reference | ||||||
| Positive | 1.722 | 1.534 | 1.934 | <0.001 | 1.593 | 1.417 | 1.791 | <0.001 |
| NOS | 1.702 | 1.502 | 1.929 | <0.001 | 1.466 | 1.292 | 1.663 | <0.001 |
| PNI | <0.001 | 0.099 | ||||||
| Negative | Reference | Reference | ||||||
| Positive | 1.102 | 1.011 | 1.202 | 0.027 | 1.082 | 0.990 | 1.184 | 0.084 |
| NOS | 1.367 | 1.248 | 1.496 | <0.001 | 0.948 | 0.854 | 1.054 | 0.325 |
MCC: mucinous cell carcinoma; SRCC: signet ring cell carcinoma; RNE: regional nodes examined; PNI: perineural invasion; NOS: not otherwise specified; NA: Unavailable.
†: Rectum includes Rectosigmoid junction.