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. 2020 Oct 2;10:16378. doi: 10.1038/s41598-020-71849-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PCME does not inhibit DENV cell-to-cell spread. (A) Quantitative analysis of DENV cell-to-cell transmission in test drug-treated viral foci. Viral E protein (reflecting DENV-positivity) was detected by immunofluorescence microscopy at 72 h and 144 h postinfection. Scale bar = 200 μm. (B) Quantitation of the number of cells per DENV E-positive focus. Data were acquired from three randomly observed foci for each treatment group. (C) Determination of the relative diameter (%) of the DENV foci under test drug treatment compared to the virus only group at 144 h. PCME = 30 μg/ml; DMSO = 0.06%. Data shown are representative confocal micrographs or means ± SEM (*P < 0.05) from 3 independent experiments.