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. 2020 Oct 2;11(10):822. doi: 10.1038/s41419-020-03030-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Liver tumor incidence in Afp-deficient (afp-/-; n = 24) and wild-type (wt, n = 32) C3H mice at 8 months after DEN injection. b Typical gross morphology of liver tumors from DEN-treated afp-/- or wt mice. c Representative microscopic features of HCC in hematoxylin and eosin (H&E)-stained liver sections from mice (Top, ×10 magnification; bottom, ×40 magnification; T: tumor; N: normal tissue). Scale bar, 100 μm. d Liver tumor numbers compared between afp-/- (n = 19) and wt (n = 24) mice. Data are expressed as the mean ± SD. e Sizes of liver tumors in afp-/- and wt mice. f Average maximal diameters of tumors compared between afp-/- and wt mice. *P < 0.05, **P < 0.01, and ***P < 0.001 versus wt mice.