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. 2020 Oct 2;13:39. doi: 10.1186/s13072-020-00363-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Properties of conserved PMDs. a Observed/expected ratios for genes and retrotransposon families inside PMDs. b Metagene plot showing methylation levels and CpG density near boundaries of PMDs. c Histograms showing distance from each RefSeq TSS and TES to its nearest PMD boundary. d PMD depth as a function of 50-kb bin PMD conservation across human samples. e PMD depth boxplots in cultured vs primary cancer samples