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. 2020 Sep 14;10(24):11197–11214. doi: 10.7150/thno.44920

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AuNP@mSiO₂@DOX-ZnO with laser irradiation induced antitumor immune responses. The percentages of CD45⁺ leukocytes (CD45⁺PI^-) (A), CD4⁺ T cells (CD45⁺CD3⁺CD4⁺PI^-) (B), CD8⁺ T cells (CD45⁺CD3⁺CD8⁺PI^-) (C) and activated CD8⁺ T cells (CD45⁺CD3⁺CD8⁺ CD44⁺CD62L^-PI^-) in tumor (D) were analyzed by flow cytometric analysis. Statistical significance was calculated by the t-test. *P < 0.05, **P < 0.01, ***P < 0.001. Data was presented as mean ± SD (n=5). The error bars represent the standard deviation. L refers to laser irradiation.