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. 2020 Sep 2;10(24):11049–11062. doi: 10.7150/thno.49168

Figure 3.

Figure 3

SE-derived ncRNAs regulate malignant tumor proliferation. A.The transcription factor SOX2 and p63 can bind to the SE region upstream of lncRNA CCAT1 to promote its expression. The obtained CCAT1 can form transcription complexes with SOX2 and p63 to regulate the expression of EGFR, leading to the malignant proliferation of SCC cells through the MEK/ERK1/2 and PI3K/AKT pathways. B. That KLF6 super enhancer was deleted will induce the over-expression of miR-1301, thereby inhibiting hepatoma cell proliferation by inducing p21and p53 in a p53-dependent manner. C. SE-derived lncRNA UCA1 interacts with AMOT to promote YAP activation and nuclear translocation and induces the expression of YAP's target genes, thereby driving the development of ovarian cancer. D. The transcription factor TP63 binds to the SE region upstream of LINC01503 to activate its expression; activated SE-derived LINC01503, in combination with EBP-1 and ERK2, stimulates the malignant proliferation of esophageal squamous cell carcinoma (ESCC) cells by activating the PI3K/AKT1 and ERK/MAPK signaling pathways.