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Representative dose-response curves of 14a and 14b in GIRK assays using human HEK293 cells expressing mGlu2/3 receptors. In vitro affinity of 14a and 14b with (A) mGlu2 GIRK assay and (B) mGlu3 GIRK assay with the control mGlu2/3 NAM MNI-137. As a non-competitive mode of action, 14a (C) and 14b (D) showed right shift of mGlu2 dose-response curves and decreased maximal response with increasing glutamate concentration.
