Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Synthesis of mGlu2 NAMs 14a-14g. Reactions and conditions: (i) POCl3, 100 oC 1 h, 64% yield; (ii) Ar1-B(OH)2, Pd(PPh3)4, K2CO3, 1,4-Dioxane/H2O, 100 oC, overnight, 80%-72% yield; (iii) NaBH3CN, AcOH, 25oC, 5 min; (iv) Ar2-CH2Cl,K2CO3, MeCN, r.t., 4 h, 52%-42% yield; (v) ammonia 7 M in MeOH, 25 oC, 4 h, 80%-70% yield. (B) Chemical structures of mGlu2 NAMs 14a-14g.
