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. 2020 Sep 14;10(24):11264–11277. doi: 10.7150/thno.47039

Figure 5.

Figure 5

Copy number amplification related eRNAs and correlated genes in lung adenocarcinoma. A. Correlation between the global expression of eRNAs in lung adenocarcinoma samples and the genomic copy number amplification level. B. Correlation between the global expression of eRNAs in lung adenocarcinoma samples and the genomic mutation burden of non-silent mutations. C. Models of the definition of copy number amplification-related eRNAs. Red bars in the chromosome indicate the copy number level of eRNA regions and blue bars in the chromosome indicate the copy number level of eRNA-related genes. Amplification of the copy number of eRNA regions will lead to upregulated expression of eRNA-related genes. D. Genomic annotation of the FOXO6 region. The orange bar indicates the genomic location and length of three FOXO6-eRNAs, and the red bar indicates the segment of the copy number of specific genomic regions. E. The expression of FOXO6-eRNA was significantly associated with the copy number level of the eRNA region. F. The expression of FOXO6-eRNA was significantly higher in samples with EGFR mutations. G. The expression of FOXO6 was significantly higher in samples with EGFR mutations.