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TLR5 restoration promotes DOX-induced damage in TLR5-deficient mice. (A) TLR5 protein expression (n = 6). (B) The ratio of heart weight to tibia length (n = 10). (C) Serum concentration of CK-MB (n = 6). (D) Ejection fraction in mice with AAV9-TLR5 (n = 6). (E) The levels of 4-HNE in DOX-treated hearts (n = 6). (F) Bax expression (n = 6). (G) The mRNA levels of inflammatory factors (n = 6). *P < 0.05 versus KO Saline; #P < 0.05 versus KO DOX group.
