Skip to main content
. 2021 Jan 18;51(1):7–13. doi: 10.1016/j.medmal.2020.09.013

Table 1.

Description of the clinical trials registered for the prophylaxis of COVID-19.

n = 112 (%)
Treatment
 Anti-malarial drugs
  (Hydroxy)chloroquinea 69 (62)
  Mefloquine
 Vaccines 1 (1)
  BCG vaccine 12 (11)
  Mycobacterium w 1 (1)
  Mycobacterium s manresensis 1 (1)
  Measles vaccines 1 (1)
 Antiviral drugs
  Lopinavir/Ritonavir 3 (3)
  Nitazoxanide 3 (3)
  Interferonb 2 (2)
  Nitric oxide 2 (2)
  Tenofovir + emtricitabine 2 (2)
  Bromhexine 2 (2)
  Arbidol 2 (2)
  Favipiravir 1 (1)
 Antibiotics and antiseptics
  Azithromycin 3 (3)
  Ivermectin 2 (2)
  Povidone-iodine 2 (2)
 Probiotics
 Immune modulators
  Lactobacillus coryniformis K8 1 (1)
  Convalescent serum or purified immunoglobulins 3 (3)
  PUL-042 inhalation 1 (1)
  Quercetin 1 (1)
  QuadraMune 1 (1)
  Lactoferrin 1 (1)
  Levamisole + isoprinosine 1 (1)
 Others
  Thiazide + calcium blocker 1 (1)
  Mesenchymal stem cells 1 (1)
  Melatonin 1 (1)
Targeted populationc
 Medical workers 70 (63)
 Patients relatives 20 (18)
 At-risk individuals 14 (13)
 Others 16 (14)
Administration moded
 Oral 83 (78)
 Intradermal 14 (13)
 Inhaled/spray 6 (6)
 Intravenous 2 (2)
 Others 2 (2)
 Unspecified 6 (6)
Study design
 Randomized 98 (88)
 Non-randomized 13 (12)
 Unspecified 1 (1)
Total number of planned inclusions
 200 and less 26 (23)
 201–999 47 (42)
 1000 and more 38 (34)
 Unspecified 1 (1)
a

9 trials included an association of hydroxychloroquine with other drugs: hydroxychloroquine + azithromycin (two trials), hydroxychloroquine + arbidol (two trials), hydroxychloroquine + bromhexine, hydroxychloroquine + tenofovir + emtricitabine, hydroxychloroquine + lopinavir/ritonavir (two trials), hydroxychloroquine + ivermectin + zinc + vitamin C + povidone-iodine.

b

Interferons are simultaneously immune modulators and antivirals.

c

8 trials included several categories.

d

1 trial included both inhaled and oral treatments.