Figure 1.

The effects of modulating chemokines and chemokine receptors involved in MS or EAE. Several studies investigated the roles of chemokines and chemokine receptors on the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) through targeting them directly (pink boxes), with specific agents acting as antagonists, receptors blockers, or antibodies. Moreover, some current MS or EAE drugs could indirectly modulate the expression of these chemokines and chemokine receptors (blue boxes).

Abbreviations: EAE, experimental autoimmune encephalomyelitis; MS, multiple sclerosis.