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. 2020 Aug 13;18(5):597–605. doi: 10.1007/s11914-020-00616-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Epigenetic enzymes deregulated during osteoporosis. Epigenetic enzymes deregulated in skeletal stem cells during the onset of osteoporosis leading to reduced osteoblast numbers and function. Upregulation of EZH2 and upregulation of DNMT1 inhibits WNT signalling; downregulation of ASH1L l suppresses HOX genes; upregulation of HDAC1 inhibits Notch signalling; downregulation of TET1/2 suppresses Runx2; downregulation of SETD2 and upregulation of KDM5A inhibits BMP2 signalling