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. 2020 Oct 3;11(10):826. doi: 10.1038/s41419-020-03028-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Mice were topically treated daily with IMQ at 8:00 am and with GSK126 or Vehicle respectively at 16:00 pm for seven days. b Phenotype of mice in different groups on day 8. c The epidermis thickness of the back lesions of mice was observed by H&E staining (n = 9). d The protein levels of EZH2, H2K27me3, and KLK8 were detected by Western Blotting. Scale bar = 100 μm. e, f Ki67 and PCNA positive cells in the back lesions of mice were examined by Immunofluorescence analysis (n = 9). Scale bar = 100 μm. *P < 0.05; ***P < 0.001.