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. 2020 Oct 3;9(10):e1184. doi: 10.1002/cti2.1184

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© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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An overview of increases (↑) and decreases (↓) of the blood immune/senescence markers and the tumor immune infiltrate markers according to age and increasing frailty level. Notably, for some markers (not shown in this figure), the highest levels were present in the middle age category (e.g. blood levels of MCP‐1, sCD25, TIM‐3, miR‐19b, miR‐20a, miR‐195), while for other markers, lowest levels were present in the middle age category (PD‐L1 in blood, and sTILs % in tumor). IC, Immune checkpoint.