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. 2020 Oct 4;10(6):e181. doi: 10.1002/ctm2.181

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© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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graphic file with name CTM2-10-e181-g001.jpg — BRD4 mRNA is inversely correlated with OS in patients with glioma and relates to glioma histology and GBM subtype. (A‐B) BRD2, BRD3, BRD4 correlated with OS of patients with glioma. TCGAs Equation (A), CGGAs Equation (B, C) datasets were used for survival analysis in primary/recurrent glioma/glioma. The median of the data was sampled to distinguish BRD low‐ and high‐expression in patient samples. (D‐E) CGGAseq and GSE16011mic datasets were used to estimate the correlation between BRD4 mRNA expression and tumor grade (WHO grade). (E) mRNAs of different histologies were examined with CGGAseq and GSE16011mic datasets, which oligodendroglioma (O), anaplastic oligodendroglioma (AO), oligoastrocytoma (OA), anaplastic oligoastrocytoma (AOA), astrocytoma (A), anaplastic astrocytoma (AA), and GBM. (F) The expression features in GBM subtypes were also explored with the TCGA and CGGA datasets. (G ,H) Protein expressions of BRD4 in normal and tumor tissues were detected by western blot. Data are shown as means ± SD, n = 5, #P = NS, *P < .05,**P < .01, ***P < .001, ****P < .0001, Student's t‐test. (I) IHC staining in normal and tumor tissues (× 40 magnification, scale bar = 200 µm)

graphic file with name CTM2-10-e181-g002.jpg — BRD4 mRNA is inversely correlated with OS in patients with glioma and relates to glioma histology and GBM subtype. (A‐B) BRD2, BRD3, BRD4 correlated with OS of patients with glioma. TCGAs Equation (A), CGGAs Equation (B, C) datasets were used for survival analysis in primary/recurrent glioma/glioma. The median of the data was sampled to distinguish BRD low‐ and high‐expression in patient samples. (D‐E) CGGAseq and GSE16011mic datasets were used to estimate the correlation between BRD4 mRNA expression and tumor grade (WHO grade). (E) mRNAs of different histologies were examined with CGGAseq and GSE16011mic datasets, which oligodendroglioma (O), anaplastic oligodendroglioma (AO), oligoastrocytoma (OA), anaplastic oligoastrocytoma (AOA), astrocytoma (A), anaplastic astrocytoma (AA), and GBM. (F) The expression features in GBM subtypes were also explored with the TCGA and CGGA datasets. (G ,H) Protein expressions of BRD4 in normal and tumor tissues were detected by western blot. Data are shown as means ± SD, n = 5, #P = NS, *P < .05,**P < .01, ***P < .001, ****P < .0001, Student's t‐test. (I) IHC staining in normal and tumor tissues (× 40 magnification, scale bar = 200 µm)