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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Toxicol Lett. 2020 Apr 19;329:38–46. doi: 10.1016/j.toxlet.2020.04.012

Figure 5. PFOA induced epigenetic changes in mice liver.

Figure 5.

(A) Histograms demonstrating quantification of 5-mC levels from liver genomic DNA. Increased PFOA concentration induces hypo-methylation (B) Histograms quantifying Dnmts mRNA expression levels. The expression levels of Dnmt1 increased and Dnmt3a decreased significantly with the increased concentration of PFOA (C) Histograms quantifying Tets mRNA expression levels. Tet1 expression levels were elevated dose-dependently. The expression levels were normalized with GAPDH. n = 3 for all experimental data. PFOA treatment concentrations are shown as the mass in legends per kg mouse per day. Significance codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1.

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