Table 1. Published trials of cardioneuroablation in patients with a combination of different vagal induced bradyarrhythmia.

*In the original paper, results of 21 patients were presented. However, in methods section, the diagnoses were VVS in 6, AVB in 7, and SND in 13. As a possible explanation of this difference, there was overlapping of those conditions in some of the cases. The procedure had not been performed due to anatomical anomaly in 1 of 21 cases.

**All patients and 9 of 20 patients completed their 6 and 12-month follow-up, respectively. *** On Holter recordings, second degree AVB was detected in 3 of 12 VVS cases. §Patients who were referred permanent pacemaker implantation and had at least one syncope episode attributable to VVS, AVB, or SND were included in studies. In some of the cases, there was overlapping of these conditions. In such a situation, the most possible diagnosis for syncope occurrence was selected after a detailed history, ECG evaluation, and analysis of Holter recordings or HUT results. AVB, atrioventricular block; CI, cardioinhibitory; HUT, head-up tilt table test; M, mixed; NI, not indicated; SND, sinus node dysfunction; VVS, vosavagal syncope

Trial			Pachon7	Aksu8	Rivarola45	Debruyne46	Aksu43§	Aksu44§
Age (years)			47 ± 16	42 ± 14	34 ±13	41 ± 18	39 ±14	39 ±14
Follow-up (months)			9 ± 4	9 ± 3	22 ±11	NI**	9 ± 6	14 ±17
		VVS	5*	8	4	12	25	46
Case number		SND	7*	7	1	8	15	8
		AVB	13*	7	9	0***	9	11
	VVS	HUT	CI	CI or M	CI	CI or M	CI or M	CI or M
		Holter	+	+	+	+	+	+
Diagnostic tools		Exercise	+	+	+	+	+	+
	SND	HUT	+	-	+	+/-	-	-
		Holter	+	+	+	+	+	+
		Exercise	+	+	+	+	+	+
	AVB	HUT	+	-	+	NI	-	-
		Holter	+	+	+	NI	+	+
		Exercise	+	+	+	NI	+	+
Pre-enrollment syncope burden (n)		VVS	NI	≥3	≥3 (syncope or presyncope)	≥2 or 1 with an injury or an accident	≥3	≥3
		SND	NI	≥3	NI	NI	≥1	≥1
		AVB	NI	≥3	NI	NI	≥3	≥3
Atropine challenge test			All cases	SND and AVB	All cases	All cases	All cases