Table 1.

Optimization of the Reaction Conditions

entry	catalyst	solvent (M)	time [h]	yield (%)	ee (%)
1	-	PhMe (2)	24	50	-
2	1a	PhMe (2)	23	86	0
3	1b	PhMe (2)	22	94	0
4	1c	PhMe (2)	20	87	11
5	1d	PhMe (2)	20	90	−28
6	1e	PhMe (2)	4	93	43
7	1f	PhMe (2)	7	91	34
8	1g	PhMe (2)	5	93	46
9	1h	PhMe (2)	4	93	58
10	1i	PhMe (2)	4	92	55
11	1j	PhMe (2)	5	95	50
12	1k	PhMe (2)	4	94	58
13	1l	PhMe (2)	4	92	59
14	1m	PhMe (2)	18	92	53
15	1n	PhMe (2)	3	93	71
16a	1o	PhMe (2)	3	93	76
17	1o	PhMe (0.5)	16	91	84
18	1o	PhMe (0.2)	20	89	86
19	-	PhMe (0.2)	24	trace	-
20	1o	TBME (0.2)	24	86	85
21	1o	CHCl3 (0.2)	24	92	75
22a	1o	PhCF3 (0.2)	24	92	79
23	1o	PhH (0.2)	24	92	84
24	1p	PhMe (0.2)	22	92	85
25	1q	PhMe (0.2)	24	92	88
26b	1q	PhMe (0.2)	34	89	88
27b,c	1q	PhMe (0.2)	72	90	93

^aReaction mixture was partially heterogeneous.

^bReaction was performed with 10 mol % catalyst.

^cReaction was performed at −10 °C.