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. 2020 Sep 30;12:9351–9362. doi: 10.2147/CMAR.S263222

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© 2020 Chen et al.

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MiR-107 bound to HMGB1. (A) HMGB1 site information on miR-107 targets. Prediction was performed by using the TargetScan (http://www.targetscan.org/vert_72/) website. (B) Detection of the luciferase activities of CircCFL1-wt and CircCFL1-mut by dual-luciferase reporter gene experiment. (C) RNA pull-down assay was performed to detect whether miR-107 bound to HMGB1. (D) MiR-107 inhibited the expression of HMGB1. (E) HMGB1 expression after CircCFL1 overexpression and knockdown was detected through qPCR. *p < 0.05, **p < 0.01, ***p < 0.001.