Table 3.

Potential Targets in TNBC

Targets	Characteristic	Regimen
pRb	Substrate of CDK4/6	Palbociclib + MLN0128
FGF13	Overexpresses in the HM model of TNBC	Unclear FGF13 inhibitor
FGFR3	Correlates with poor OS	Unclear
FGFR3-TACC3 fusion gene	Activates oncogenic driver function of FGFR3	Unclear
MSN, NONO, CREB	MSN correlates with poor OS	MSN/NONO inhibitor, CREB inhibitor + docetaxel
WEE1, ATR	Synergistic effect in TNBC	WEE1 inhibitor AZD1775 + ATR inhibitor AZD6738
Src tyrosine kinase	Regulating osteoclastic bone	Dasatinib

Abbreviations: pRb, retinoblastoma protein; CDK4/6, cyclin-dependent kinase 4/6; FGF13, fibroblast growth factor 13; FGFR3, fibroblast growth factor receptor 3; MSN, moesin; CREB, element-binding protein; ATR, rad3-related protein.