Skip to main content
. 2020 Sep 30;13:9701–9719. doi: 10.2147/OTT.S256378

Figure 6.

Figure 6

ITM2B was decreased in lung cancer tissues and inhibited tumor progression. (A) ITM2B levels in lung cancer tissues compared to normal lung tissues according to TCGA database; (B)ITM2B levels in different stages of lung cancer and normal lung tissues analyzed using RT-qPCR. (C)ITM2B transcription levels in 10 lung cancer cell lines; (D) ITM2B level in LTEP-a-2 cells after mock, empty vector lentivirus, and OE-ITM2B lentivirus treatment for 24 hours; (E) Proliferation rate of LTEP-a-2 cells were assessed using CCK-8 assays every 24 hours following treatment with OE-ITM2B lentivirus compared with empty vector lentivirus treatment; (F) Ki67 levels in LTEP-a-2 cells were assessed using RT-qPCR following OE-ITM2B lentivirus treatment compared with empty vector lentivirus treatment; (G) Tumor growth rate of lung cancer xenograft following OE-ITM2B lentivirus treatment compared with empty vector lentivirus treatment; (H) Kaplan–Meier overall survival curve in mice with OE-ITM2B lentivirus treatment compared with empty vector lentivirus treatment. Mean±SEM, *P<0.05, ****P<0.001, NS, no statistical significance.