Table 3.
Effect of 80% Hydromethanolic Root Extract of Echinops kebericho on Carrageenan-Induced Paw Edema Model in Mice
| Change in Edema Volume (mL) Mean ± SEM | |||||
|---|---|---|---|---|---|
| Treatment Groups | 0hr | 1hr | 2hr | 3hr | 4hr |
| IND25 mg/kg | 0.46 ± 0.03 | 0.22 ± 0.005b3(51.48) | 0.19 ± 0.006b3c2 (56.06) | 0.18 ± 0.006b3 (69.88) | 0.12± 0.006b3c3d2 (71.54) |
| DW10 mg/kg | 0.45 ± 0.04 | 0.46 ± 0.01 | 0.44 ± 0.008 | 0.59 ± 0.03 | 0.43 ± 0.01 |
| EK100 mg/kg | 0.40 ± 0.02 | 0.27 ± 0.02b3 (41.18) | 0.25 ± 0.01a2b3 (43.18) | 0.21 ± 0.01b3 (64.77) | 0.20 ± 0.01a3b3e3 (54.64) |
| Ek200 mg/kg | 0.40 ± 0.02 | 0.26 ± 0.02b3 (41.91) | 0.22 ± 0.01b3 (49.62) | 0.20 ± 0.01b3 (66.48) | 0.17 ± 0.004b3e1 (61.54) |
| EK400 mg/kg | 0.42 ± 0.02 | 0.26 ± 0.02b3 (42.65) | 0.19 ± 0.04b3c2 (56.04) | 0.17 ± 0.04b3 (69.57) | 0.13 ± 0.002b3c3d2 (70.00) |
Notes: Values are expressed as Mean ± S.E.M (n = 6); analysis was performed with One-Way ANOVA followed by Tukey post Hoc multiple comparison test. a = as compare to +ve control, b = as compare to -ve control, c = as compare to 100 mg/kg EK, d = as compare to 200 mg/kg EK, e = as compare to 400 mg/kg EK, 3p < 0.001, 2p < 0.01, 1p < 0.05. The data in parenthesis showed the percentage inhibition of paw edema.
Abbreviations: IND, Indomethacin (25 mg/kg); DW, distilled water (10 mL/kg); EK100mg/kg, Echinops kebericho extract 100 mg/kg; EK200 mg/kg, Echinops kebericho extract 200 mg/kg; EK400 mg/kg, Echinops kebericho extract 400 mg/kg.