Comparison of the main characteristics determined in patients with early COPD (versus controls) in the three cohorts studied here (our own (SPAIN), ECLIPSE and COPDGene). ↓ Indicates reduced in cases, ↑ indicates increased in cases, ∼ indicates similar in patients and controls, and NA means not available in that cohort. Orange, pink and yellow rows indicate, respectively, reproducibility of findings in three out of the three cohorts, two out of two cohorts or two out of three cohorts where this information was available. For further explanations, see text.