Figure 7.

Antitumor Efficacy and Toxicity of BA, BAD, and BAL in Nude Mice Bearing A549 Tumor Xenografts In Vivo

(A) Changes of body weight (g) before and after treatment with BA, BAD, and BAL in nude mice. (B) Tumor volume of A549-bearing nude mice treated with BA, BAD, and BAL on day 24. (C) Changes of tumor volume with different groups in nude mice. (D) Tumor inhibitory rates (%) of A549-bearing nude mice treated with BA, BAD and BAL on day 24. (E) Tumor weights (g) of A549-bearing nude mice treated with BA, BAD, and BAL on day 24, after which the mice were humanely sacrificed. (F) Photograph of tumor on day 24 when the mice were humanely sacrificed. (G) The results of CD31 in tumor tissues were analyzed by immunohistochemistry. (H) The results of tumor mass H&E staining; the yellow arrow points to the necrotic tumor cells (means ± SD, n = 5). t test: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, dose groups versus control.