Table 3.
Top canonical pathways, upstream regulators, molecular and cellular functions related to radiation sensitivity signature
| p-value | p-value (range) | |
|---|---|---|
| Top canonical pathways | ||
| Pathogenesis of multiple sclerosis | 1.35 × 10-4 | |
| IL-17A signaling in gastric cells | 1.10 × 10-3 | |
| Granulocyte adhesion and diapedesis | 4.17 × 10-3 | |
| Agranulocyte adhesion and diapedesis | 4.99 × 10-3 | |
| Phenylethylamine degradation I | 7.85 × 10-3 | |
| Top upstream regulators | ||
| PDE4B | 5.40 × 10-5 | |
| LILRB4 | 7.55 × 10-5 | |
| RARRES3 | 1.01 × 10-4 | |
| IFNL4 | 1.61 × 10-4 | |
| TICAM1 | 2.36 × 10-4 | |
| Top molecular and cellular functions (related molecules) | ||
| Cellular movement (9) | 5.00 × 10-2 to 1.13 × 10-5 | |
| Cell death and survival (15) | 3.02 × 10-2 to 2.26 × 10-5 | |
| Amino acid metabolism (3) | 3.74 × 10-2 to 1.97 × 10-3 | |
| Cell morphology (4) | 4.62 × 10-2 to 1.97 × 10-3 | |
| Cell to cell signaling and interaction (10) | 4.62 × 10-2 to 1.97 × 10-3 |