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. 2020 Oct 4;9(10):e1186. doi: 10.1002/cti2.1186

Figure 6.

Figure 6

Gasdermins augment the mitochondrial apoptotic pathway. (a) Caspase‐3, which is activated by intrinsic or extrinsic apoptotic pathway, cleaves GSDME to generate the pyroptotic GSDMENT fragment, which permeabilises the mitochondria membrane, releases cytochrome c (Cyt c) and activates the apoptosome in cancer cells and immortalised bone marrow‐derived macrophages (iBMDMs). Cyt c released through GSDMENT mitochondrial pores, in turn, drives caspase‐3 activation and GSDME cleavage. (b) Canonical or non‐canonical inflammasome‐induced GSDMDNT fragment can permeabilise the mitochondria and release Cyt c, finally enhancing the mitochondrial apoptotic pathway in cancer cells and iBMDMs. TNFR1, tumor necrosis factor receptor type 1; Cyt c, cytochrome c; CASP‐3, caspase‐3; CASP‐1, caspase‐1; CASP‐11, caspase‐11.