Table 2.

The role of gasdermins in autoimmunity diseases

Autoimmunity diseases	Gasdermins	Study type	Biofunctions	Reference
Multiple sclerosis (MS)	GSDMD	Experimental evidence	GSDMD‐mediated pyroptosis inducing neuroinflammation via promoting and recruiting active T‐cell infiltration into the central nervous system (CNS)	78
Systemic sclerosis (SSc)	GSDMA	GWAS	The variant rs3894194, a missense mutation of GSDMA, is a novel susceptibility locus for SSc	79
Inflammatory bowel disease (IBD)	GSDMA GSDMB GSDMD	GWAS Experimental evidence	GSDMA and GSDMB were proved to be IBD susceptibility genes; GSDMD‐mediated pyroptosis contributes to IBD	80, 81, 82, 83
Rheumatoid arthritis (RA)	GSDMB GSDMD	GWAS Experimental evidence	GSDMB locus is associated with the risk of RA; GSDMD‐conferred monocyte pyroptosis is involved in RA	84, 85, 86
Familial Mediterranean fever (FMF)	GSDMD	Experimental evidence	GSDMD‐mediated pyroptosis is critical for autoinflammatory pathology in FMF	89
Type 1 diabetes (T1D)	GSDMB	GWAS	A risk allele of rs2290400 in GSDMB probably determines the risk of T1D predominantly in early childhood	90, 91, 92, 93

GWAS, genome‐wide association studies.