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. 2020 Sep 10;22(5):4278–4288. doi: 10.3892/mmr.2020.11503

Table IV.

Pearson's correlation coefficients of gene expression.

Gene expression
Variable mTOR PI3KCB AKT1 NF-κB HIF1α AMPKα1 CASP8 FAS ULK1
mTOR
  r-value 1 0.721c 0.792c 0.640c 0.281a 0.630c 0.607c 0.409c 0.221
  Significance (bilateral) N/A 0.000 0.000 0.000 0.017 0.000 0.000 0.000 0.063
  N 72 72 72 72 72 72 72 72 72
PI3KCB
  r-value 0.721c 1 0.741c 0.572c 0.293a 0.835c 0.372b 0.019 0.150
  Significance (bilateral) 0.000 N/A 0.000 0.000 0.013 0.000 0.001 0.876 0.208
  N 72 72 72 72 72 72 72 72 72
AKT1
  r-value 0.792c 0.741c 1 0.646c 0.298a 0.666c 0.508c 0.181 0.189
  Significance (bilateral) 0.000 0.000 N/A 0.000 0.011 0.000 0.000 0.127 0.111
  N 72 72 72 72 72 72 72 72 72
NF-κB
  r-value 0.640c 0.572c 0.646c 1 0.226 0.674c 0.658c 0.281a 0.021
  Significance (bilateral) 0.000 0.000 0.000 N/A 0.056 0.000 0.000 0.017 0.861
  N 72 72 72 72 72 72 72 72 72
HIF1α
  r-value 0.281a 0.293a 0.298a 0.226 1 0.433c 0.525c 0.482c 0.728c
  Significance (bilateral) 0.017 0.013 0.011 0.056 N/A 0.000 0.000 0.000 0.000
  N 72 72 72 72 72 72 72 72 72
AMPKα1
  r-value 0.630c 0.835c 0.666c 0.674c 0.433c 1 0.557c 0.137 0.342c
  Significance (bilateral) 0.000 0.000 0.000 0.000 0.000 N/A 0.000 0.250 0.003
  N 72 72 72 72 72 72 72 72 72
CASP8
  r-value 0.607c 0.372c 0.508c 0.658c 0.525c 0.557c 1 0.762c 0.467c
  Significance (bilateral) 0.000 0.001 0.000 0.000 0.000 0.000 N/A 0.000 0.000
  N 72 72 72 72 72 72 72 72 72
FAS
  r-value 0.409c 0.019 0.181 0.281a 0.482c 0.137 0.762c 1 0.501c
  Significance (bilateral) 0.000 0.876 0.127 0.017 0.000 0.250 0.000 N/A 0.000
  N 72 72 72 72 72 72 72 72 72
ULK1
  r-value 0.221 0.150 0.189 0.021 0.728c 0.342b 0.467c 0.501c 1
  Significance (bilateral) 0.063 0.208 0.111 0.861 0.000 0.003 0.000 0.000 N/A
  N 72 72 72 72 72 72 72 72 72
a

P<0.05

b

P<0.01

c

P<0.001. PI3KCB, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit β isoform; AKT1, threonine kinase 1; HIF1α, hypoxia-inducible factor 1α; AMPKα1, protein kinase AMP-activated catalytic subunit α1; CASP8, caspase 8; FAS, Fas cell surface death receptor; ULK1, unc-51 like autophagy activating kinase 1; N/A, not applicable.